Angiotensin II Substrate refers to angiotensin I, a decapeptide (10 amino acids) that serves as the direct precursor for angiotensin II in the renin-angiotensin system (RAS). Generated by renin-mediated cleavage of angiotensinogen, angiotensin I is enzymatically processed by angiotensin-converting enzyme (ACE) to release angiotensin II, a potent vasoconstrictor critical for blood pressure regulation, fluid balance, and cardiovascular homeostasis. As the substrate for ACE, this peptide enables the conversion of an inactive precursor into the bioactive octapeptide, driving downstream signaling through AT1 and AT2 receptors. In pharmacological research, the Angiotensin II Substrate is used to investigate ACE specificity, enzyme kinetics, and the development of ACE inhibitors—drugs that block angiotensin II formation to treat hypertension, heart failure, and diabetic nephropathy. Its role as a central intermediate underscores its importance in understanding RAS activation and therapeutic strategies targeting cardiovascular and renal disorders.

Chemical Formula: C50H72N13O15P

Molecular Weight: 1126.20

Sequence: Asp-Arg-Val-Tyr(PO3H2)-Ile-His-Pro-Phe

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only