Angiotensin I, human is a decapeptide (10 amino acids) generated by renin-mediated cleavage of the plasma protein angiotensinogen in the renin-angiotensin system (RAS). Although biologically inactive itself, it serves as the immediate precursor to the potent vasoconstrictor angiotensin II, formed via enzymatic conversion by angiotensin-converting enzyme (ACE) primarily in the lungs. This conversion is critical for regulating blood pressure, fluid balance, and vascular tone, as angiotensin II activates AT1 and AT2 receptors to induce vasoconstriction, aldosterone secretion, and sodium retention. In pharmacological research, human Angiotensin I acts as a tool to investigate RAS signaling pathways, ACE substrate specificity, and the development of ACE inhibitors—drugs widely used to treat hypertension, heart failure, and diabetic kidney disease by blocking the formation of angiotensin II. Its role as a central intermediate underscores its importance in understanding cardiovascular homeostasis and the therapeutic targeting of the RAS cascade.

Chemical Formula: C62H89N17O14

Molecular Weight: 1296.50

Sequence: Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu

Purity: From crude to 98%

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