α-Conotoxin EI is a neurotoxic peptide isolated from the venom of the cone snail Conus ermineus, specifically targeting nicotinic acetylcholine receptors (nAChRs). By binding to the ligand-binding site of nAChRs, α-Conotoxin EI disrupts cholinergic signaling, inhibiting neuromuscular transmission and neuronal communication, which is critical for the snail’s predatory and defensive mechanisms. In research, it serves as a valuable tool to investigate the structure-function relationships of nAChRs, particularly in understanding receptor subtypes involved in pain, muscle function, and neurological disorders. Its high affinity and selectivity also make it a promising lead for developing therapeutic agents targeting nAChR-related conditions, such as chronic pain or autoimmune diseases, while shedding light on the evolutionary diversity of venom-derived bioactive molecules.

Chemical Formula: C83H123N27O27S5

Molecular Weight: 2091.39

Sequence: Arg-Asp-Hyp-Cys-Cys-Tyr-His-Pro-Thr-Cys-Asn-Met-Ser-Asn-Pro-Gln-Ile-Cys-NH2

Purity: From crude to 98%

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