1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (CAS 162148-48-3) is supplied as a Partially protected cyclen chelator precursor. In research synthesis, it is most relevant to macrocyclic chelator and DOTA-related synthesis and stepwise chelator functionalization and metal-binding scaffold synthesis.

Use as a macrocyclic intermediate where partial carboxymethyl protection enables controlled derivatization; it is not a peptide monomer. For reproducible work, confirm identity and protection state against the COA before transferring conditions from a related analog.

Product Information

Use in Macrocyclic Chelator Synthesis

The cyclen core provides a tetraazamacrocycle used as a foundation for metal-chelator chemistry. Partial carboxymethyl protection allows further substitution to be staged rather than exposing all donor-arm positions at once.

Protection-State Control

The value of this intermediate lies in controlled functionalization. Route design should track which nitrogens are substituted, which carboxymethyl groups are protected and which positions remain available for further derivatization.

Procurement and Identity

For macrocyclic intermediates, small differences in substitution pattern can create different downstream chelators. CAS, formula, structural representation and lot-specific analytical data should therefore be reviewed together.

Additional chemistry is available in the current small-molecule range.

Product Documents

MSDS - 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane (AS4228)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Why does the exact derivative matter?

1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.

Can a close analog replace 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane?

Not safely by name alone. For 1,7-Bis(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.

What should procurement verify?

Match the product to CAS 162148-48-3 and the lot-specific COA rather than relying only on a shorthand chemical name.

Research Use Only.