$48.57 - $142.86
Fmoc-Phe(3-I)-OH (CAS 210282-31-8) is an Iodo-substituted amino-acid derivative used in halogenated amino-acid synthesis and aromatic/alkyl derivatization. Its main synthetic value is halogen-enabled derivatization, cross-coupling precursor chemistry and peptide/SAR studies.
Use when the iodine substituent is a deliberate synthetic or electronic handle; avoid conditions that unintentionally remove or exchange it. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | Fmoc-Phe(3-I)-OH |
| Catalog No. | AS4250 |
| CAS No. | 210282-31-8 |
| Molecular Formula | C24H20INO4 |
| Molecular Weight | 513.32 g/mol |
| Compound Type | Iodo-substituted amino-acid derivative |
| Primary Research Use | Halogenated amino-acid synthesis and aromatic/alkyl derivatization |
Role of the Halogenated Residue
Fmoc-Phe(3-I)-OH introduces a iodinated amino-acid motif into peptide or small-molecule synthesis. Halogen substitution can alter local electronics, hydrophobicity and conformational preferences while preserving the core amino-acid connectivity.
SAR and Derivatization
The value of a halogenated residue is position-specific. In aromatic iodides, the iodine can also serve as a synthetic handle for selected cross-coupling or derivatization routes; fluorinated residues are more often retained as final structural features.
Selection Considerations
Verify substitution position and stereochemistry before ordering. Positional isomers with the same elemental composition can have materially different synthetic and biological behavior.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-Phe(3-I)-OH (AS4250)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Fmoc-Phe(3-I)-OH mainly used for?
Halogenated amino-acid synthesis and aromatic/alkyl derivatization.
What is the critical identity check?
Confirm CAS 210282-31-8, stereochemistry or positional isomer where applicable, and the complete protection state.
What documentation should be matched to the lot?
Use the COA to confirm assay and analytical identity; the nominal formula is C24H20INO4 with molecular weight 513.32 g/mol.