$647.00 - $1943.00
Z-Phe-OSu (CAS 3397-32-8) is a Cbz/Z-protected amino-acid NHS active ester used in activated acyl donor for amide-bond formation. Its main synthetic value is amine acylation, solution-phase coupling and derivatization.
Use when a preactivated amino-acid acyl donor is useful; moisture and competing nucleophiles can reduce effective reactivity. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Z-Phe-OSu |
| Catalog No. | AS4267 |
| CAS No. | 3397-32-8 |
| Molecular Formula | C21H20N2O6 |
| Molecular Weight | 396.39 g/mol |
| Compound Type | Cbz/Z-protected amino-acid NHS active ester |
| Primary Research Use | Activated acyl donor for amide-bond formation |
Preactivated Amide-Bond Formation
Z-Phe-OSu is supplied as an N-hydroxysuccinimide active ester, converting the amino-acid carboxyl group into a ready acyl donor for reaction with nucleophilic amines. This can simplify selected solution-phase coupling and derivatization steps.
Protection Pattern and Selectivity
The N-protecting group and any side-chain protection define which functions remain inert during acyl transfer. Verify the complete protection state before using the active ester in a multistep route.
Handling and Reaction Control
Active esters can lose effective reactivity through hydrolysis. Dry handling, solvent selection, amine availability and reaction pH/base conditions are more important than simply increasing reagent excess.
Related options are grouped under peptide synthesis reagents. For broader route support, see specialty research chemicals.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does OSu mean in this product name?
OSu denotes an N-hydroxysuccinimide-derived active ester of the carboxyl group.
Why use a preactivated amino-acid ester?
It can simplify selected amide-forming steps by providing a ready acyl donor for an amine.
Are NHS active esters moisture sensitive?
They can hydrolyze in the presence of water, so dry handling and appropriate reaction conditions are important.