$121.00 - $121.00
Substance P (1-7) is the N-terminal heptapeptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH. This product is the free-acid form, CAS 68060-49-1, and should be distinguished from the amidated SP(1-7) form reported under a different registry number.
Because SP(1-7) lacks the native Phe-Phe-Gly-Leu-Met-NH2 C-terminal tachykinin pharmacophore, its biological effects are distinct from conventional NK1 receptor agonism. It is useful in Substance P metabolism, fragment-signaling and receptor-regulation studies.
Product Information
| Product Name | Substance P (1-7) |
| CAS No. | 68060-49-1 |
| Sequence | Arg-Pro-Lys-Pro-Gln-Gln-Phe-OH |
| One-Letter Sequence | RPKPQQF |
| Peptide Length | 7 residues |
| Molecular Formula | C41H65N13O10 |
| Molecular Weight | Approximately 900.0 Da |
| C-Terminus | Phe-OH |
Free Acid and Amidated SP(1-7) Are Different Products
CAS 68060-49-1 corresponds to RPKPQQF-OH. An amidated form, RPKPQQF-NH2, is separately registered as CAS 72226-88-1.
We recommend checking terminal chemistry before comparing published potency, molecular weight or biological data because these two forms are not chemically interchangeable.
N-Terminal Fragment Biology
SP(1-7) lacks the C-terminal sequence responsible for classical high-affinity Substance P recognition at NK1. Experimental effects should therefore be interpreted in the context of N-terminal metabolite biology rather than assumed to reproduce native Substance P pharmacology.
Research Applications
The peptide can support neuropeptide metabolism, Substance P degradation studies, N-terminal fragment signaling and receptor-regulation research.
Frequently Asked Questions
Is this product amidated?
No. It is RPKPQQF-OH.
Why does SP(1-7) sometimes have another CAS number?
The amidated and free-acid forms have different registry numbers.
Is it a conventional NK1 agonist?
No. It lacks the native C-terminal tachykinin pharmacophore.