Orexin B, rat, mouse is an endogenous neuropeptide produced in the hypothalamus of rats and mice, consisting of 33 amino acids with high structural conservation across mammalian species. It acts as a ligand for Orexin 1 (OX1) and Orexin 2 (OX2) receptors, mediating critical roles in arousal, appetite regulation, energy homeostasis, and stress responses in rodents. This peptide plays a central role in sleep-wake cycles, feeding behavior, and metabolic regulation in rats and mice. In pharmacological research, Orexin B from these species serves as a tool to investigate receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for disorders like insomnia, narcolepsy, and obesity. Its cross-species conservation underscores its utility in translational studies, offering insights into Orexin signaling pathways and drug development for both veterinary and human health. As a key component of rodent models, it supports research on sleep disorders, metabolic diseases, and stress-related conditions.

Chemical Formula: C126H215N45O34S

Molecular Weight: 2936.46

Sequence: Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Purity: From crude to 98%

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