[D-Ala2] Met-Enkephalin is a synthetic analog of the endogenous opioid peptide Met-Enkephalin, featuring a D-alanine (D-Ala) substitution at position 2. This modification enhances stability and resistance to enzymatic degradation while retaining high affinity for μ and δ opioid receptors. By mimicking the analgesic and mood-regulating effects of native enkephalins, it mediates pain relief, stress modulation, and gastrointestinal motility. In pharmacological research, this analog serves as a tool to investigate opioid receptor activation mechanisms, structure-activity relationships, and the role of peptide conformation in receptor binding. Its resistance to degradation makes it valuable for studying sustained opioid signaling and developing therapeutic candidates for pain management, addiction therapies, and psychiatric disorders.

Chemical Formula: C28H37N5O7S

Molecular Weight: 587.70

Sequence: Tyr-D-Ala-Gly-Phe-Met

Purity: From crude to 98%

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Research Use Only