Orexin A, bovine, human, mouse, rat is an endogenous neuropeptide produced in the hypothalamus, consisting of 33 amino acids with conserved structure across these species. It acts as a ligand for Orexin 1 (OX1) and Orexin 2 (OX2) receptors, mediating critical roles in arousal, appetite regulation, energy homeostasis, and stress responses. Structurally and functionally conserved, it plays a central role in sleep-wake cycles, feeding behavior, and metabolic regulation in mammals. In pharmacological research, Orexin A serves as a tool to investigate receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for disorders like insomnia, narcolepsy, obesity, and neurodegenerative conditions. Its cross-species conservation underscores its evolutionary significance and utility in translational studies, offering insights into Orexin signaling pathways and drug development for human and veterinary health.

Chemical Formula: C152H243N47O44S4

Molecular Weight: 3561.19

Sequence: Pyr-Pro-Leu-Pro-Asp-Cys-Cys-Arg-Gln-Lys-Thr-Cys-Ser-Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2-（Disulfidebridge:Cys6-Cys12,-Cys7-Cys14）

Purity: From crude to 98%

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