[Met5, Lys6] α-Neo-Endorphin (1-6) is a modified analog of the opioid peptide α-Neo-Endorphin (1-6), incorporating methionine (Met) at position 5 and lysine (Lys) at position 6. These substitutions enhance stability, resistance to enzymatic degradation, and binding specificity for μ, δ, and κ opioid receptors. Retaining bioactivity, it mediates analgesic effects, mood regulation, and immune modulation. In pharmacological research, this analog serves as a tool to investigate opioid receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for pain management, addiction therapies, and psychiatric disorders. Its truncated form and amino acid substitutions enable focused studies on receptor specificity and peptide-drug development.

Chemical Formula: C33H47N7O8S

Molecular Weight: 701.85

Sequence: Tyr-Gly-Gly-Phe-Met-Lys

Purity: From crude to 98%

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