MART-1 (26-35) (human) is a 10-amino acid peptide derived from the Melan-A/MART-1 protein, a melanoma-associated antigen highly expressed in melanocytes and melanoma cells. This peptide represents a key antigenic epitope that binds to major histocompatibility complex (MHC) class I molecules (e.g., HLA-A*02:01) for presentation to cytotoxic T lymphocytes (CTLs). Recognized by T cells as a tumor-specific antigen, MART-1 (26-35) is critical in immunotherapeutic strategies targeting melanoma, including peptide vaccines and adoptive T-cell therapies. In research, it is used to study T-cell activation, optimize antigen presentation, and enhance CTL-mediated killing of melanoma cells. Its role in immune recognition makes it a focal point for developing personalized immunotherapies aimed at harnessing the body’s immune system to combat melanoma, with efforts focused on improving its immunogenicity and clinical efficacy in cancer treatment.

Chemical Formula: C42H74N10O14

Molecular Weight: 943.12

Sequence: Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val

Purity: From crude to 98%

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Research Use Only