β-Interleukin I (163-171), human is a 9-amino-acid peptide fragment corresponding to residues 163–171 of the human Interleukin-1β (IL-1β) cytokine, a key mediator of inflammatory responses. This bioactive segment is derived from the processed form of IL-1β and retains the ability to interact with IL-1 receptors (IL-1R1/IL-1R2), contributing to signaling pathways that regulate immune cell activation, cytokine production, and fever. In pharmacological research, it serves as a tool to investigate IL-1β receptor-binding mechanisms, inflammatory signaling, and the therapeutic potential of receptor antagonists for conditions like rheumatoid arthritis, sepsis, and autoinflammatory diseases. Its role in modulating pro-inflammatory responses highlights its utility in studying immune system crosstalk and developing targeted anti-inflammatory strategies.

Chemical Formula: C39H64N12O19

Molecular Weight: 1005.01

Sequence: Val-Gln-Gly-Glu-Glu-Ser-Asn-Asp-Lys

Purity: From crude to 98%

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Research Use Only