Interleukin-1β Convertase Substrate refers to the specific amino acid sequence within the pro-interleukin-1β (pro-IL-1β) precursor that is recognized and cleaved by the enzyme caspase-1 (formerly known as interleukin-1β converting enzyme, ICE). This substrate typically includes a conserved cleavage site, such as the Asp116-Gly117 bond in human pro-IL-1β, which is essential for generating the biologically active, mature IL-1β cytokine. By facilitating the conversion of pro-IL-1β into its active form, this substrate plays a critical role in the inflammatory response, regulating immune cell activation, fever induction, and tissue repair. In pharmacological research, the Interleukin-1β Convertase Substrate serves as a tool to investigate caspase-1 activation mechanisms, validate inhibitor specificity, and explore therapeutic strategies for inflammatory diseases like rheumatoid arthritis, sepsis, and cryopyrin-associated periodic syndromes (CAPS). Its study underscores the importance of proteolytic processing in cytokine biology and underscores potential targets for anti-inflammatory drug development.

Chemical Formula: C68H105N21O23

Molecular Weight: 1584.71

Sequence: Asn-Glu-Ala-Tyr-Val-His-Asp-Ala-Pro-Val-Arg-Ser-Leu-Asn

Purity: From crude to 98%

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Research Use Only