Hypocretin (70-98) (human) is an endogenous neuropeptide corresponding to the full-length human Orexin B (Hypocretin-2), consisting of 33 amino acids (residues 70–98 of the preprohypocretin precursor). It acts as a ligand for Orexin 1 (OX1) and Orexin 2 (OX2) receptors, mediating critical roles in arousal, appetite regulation, energy homeostasis, and stress responses in humans. This peptide plays a central role in sleep-wake cycles, feeding behavior, and metabolic regulation. In pharmacological research, Hypocretin (70-98) serves as a tool to investigate receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for disorders like insomnia, narcolepsy, obesity, and neurodegenerative conditions. Its conserved sequence across species underscores its evolutionary significance and utility in translational studies, offering insights into Orexin signaling pathways and drug development for human health.

Chemical Formula: C125H214N44O37S

Molecular Weight: 2957.40

Sequence: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-Gly

Purity: From crude to 98%

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