HIV-1 Tat (1–9), sequence MDPVDPNIE, is a 9-amino-acid N-terminal peptide fragment derived from HIV-1 Tat.
Unlike the arginine-rich Tat(47–57) and Tat(49–57) protein transduction domains, Tat(1–9) is not a classical cell-penetrating peptide. Its principal research relevance is associated with interaction with dipeptidyl peptidase IV (DPPIV/CD26) and studies of HIV Tat-related immunological activity.
Product Information
| Property | Specification |
|---|---|
| Product Name | HIV-1 Tat (1–9) |
| Catalog No. | AS2690 |
| Sequence | MDPVDPNIE |
| Length | 9 amino acids |
| Peptide Class | HIV-1 Tat N-terminal fragment |
| Research Target | DPPIV / CD26 |
| Research Areas | Enzyme inhibition, HIV Tat biology, immunology, peptide–enzyme interactions |
DPPIV/CD26 Interaction
DPPIV, also known as CD26, is a membrane-associated serine protease involved in peptide processing and immune-cell regulation.
Tat(1–9) has been investigated as an N-terminal Tat-derived peptide capable of interacting with DPPIV/CD26. Structural and biochemical studies have used this sequence to examine peptide recognition within the DPPIV active site.
This gives Tat(1–9) a research profile fundamentally different from the Tat-derived CPP sequences located around residues 47–57.
Tat(1–9) vs Tat(49–57)
| Peptide | Sequence | Primary Research Context |
|---|---|---|
| Tat(1–9) | MDPVDPNIE | DPPIV/CD26 interaction |
| Tat(49–57) | RKKRRQRRR | Cell penetration / intracellular delivery |
The two sequences have the same length but originate from different functional regions of HIV-1 Tat and should not be treated as interchangeable research peptides.
Research Applications
Tat(1–9) can be used in studies involving DPPIV/CD26 interaction, enzyme inhibition, HIV Tat biology, immunological signaling, peptide–protease interactions, and structure–activity analysis.
Researchers requiring sequence analogs, residue substitutions, terminal modifications, or labeled Tat-derived peptides can use our Custom Peptide Synthesis capabilities.
Quality Control
Analytical HPLC can be used to assess chromatographic purity, while MS supports confirmation of molecular identity.
For comparative enzyme studies, sequence identity and terminal chemistry should remain consistent between experimental groups.
See Peptide Quality Control for additional information.
Frequently Asked Questions
What is the sequence of HIV-1 Tat (1–9)?
The sequence is MDPVDPNIE.
Is Tat(1–9) a cell-penetrating peptide?
It is not considered a classical TAT CPP. The best-characterized HIV-1 Tat cell-penetrating region is the highly basic domain around residues 47–57.
What is Tat(1–9) primarily studied for?
It has been studied primarily in relation to DPPIV/CD26 interaction and inhibition, HIV Tat biology, and peptide–enzyme recognition.
Research Use Only.
HIV-1 Tat (1–9) is supplied for research use only. It is not intended for therapeutic, or human use.