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H-Lys(Boc)-NH2.HCl is N6-Boc-L-lysinamide hydrochloride. The α-amino group is free as the hydrochloride salt, the lysine ε-amino group is Boc-protected, and the carboxyl group has been converted to a primary amide.
Because the C-terminus is already amidated, this reagent is not a conventional lysine carboxylic acid building block. Its value lies in terminal lysinamide motifs and protected intermediate synthesis.
Product Information
| Product Name | H-Lys(Boc)-NH2.HCl |
| Catalog No. | AS4190 |
| CAS No. | 112803-72-2 |
| Molecular Formula | C11H24ClN3O3 |
| Molecular Weight | 281.78 g/mol |
| Building Block Type | N6-Boc-L-lysinamide hydrochloride |
| Primary Applications | Lysinamide terminal motifs; protected intermediate chemistry; selective lysine derivatization; peptide-mimetic synthesis |
The C-Terminal Amide Changes Its Synthetic Role
Conversion of CO2H to CONH2 removes the normal carboxyl handle used for further backbone extension through that terminus. This makes the reagent appropriate for terminal or intermediate chemistry rather than ordinary bidirectional amino-acid coupling.
ε-Boc Leaves the α-Amine Available
The side-chain ε-NH2 remains protected, while the α-amino group can be liberated from its HCl salt and used in an appropriate coupling or derivatization step.
Salt State Affects Stoichiometry
The formula C11H24ClN3O3 and MW 281.78 g/mol include hydrochloride. Using a free-base value for reagent equivalents would introduce a systematic stoichiometric error.
Procurement and QC
Confirm CAS 112803-72-2, N6-Boc protection, primary carboxamide, L stereochemistry, and HCl salt state. PubChem lists this exact compound as not classified under its current GHS summary.
Terminal lysinamide or selectively protected lysine designs can be incorporated through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Which lysine amine is Boc-protected?
The side-chain N6/ε-amino group is Boc-protected.
Is the carboxyl group free?
No. It has been converted into a primary carboxamide.
Does the MW include HCl?
Yes. The listed formula and molecular weight include the hydrochloride salt.
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