H-Gly-Tyr-Gly-OH (Gly-Tyr-Gly; CAS 6099-08-7) is a tyrosine-centered tripeptide used as a compact model for aromatic UV behavior, Tyr-centered chemistry and analytical peptide studies.

The Gly-X-Gly context reduces side-chain complexity around tyrosine, making GYG useful for spectroscopy and chemical-modification studies. Because public records for CAS 6099-08-7 do not consistently specify a single Tyr stereochemical form, lot-specific stereochemistry should be confirmed for stereochemistry-sensitive work.

Product Information

Tyrosine Spectroscopy and Nitration Models

Gly-Tyr-Gly has been used as a simple Tyr-containing model in studies of UV absorption and tyrosine nitration. The flanking glycine residues provide a low-complexity context around the phenol, which is useful for spectroscopy and chemical-modification method development.

Analytical Identity and Method Development

Short peptides are often purchased as reference compounds because exact sequence, terminal state and stereochemistry can influence retention, ionization and fragmentation. When peak assignment matters, use the exact compound identity rather than relying only on nominal molecular mass.

Procurement and QC Considerations

For research use, match the requested purity and documentation to the experiment. Analytical or quantitative studies benefit from lot-specific HPLC and MS data, while metabolomics or sequence-isomer work may require additional identity controls.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Analytical Fit and Sample Handling

For aromatic peptide models, lot-specific HPLC and mass data help establish the starting impurity profile before oxidation or stability work. A reported chromatographic purity value should be interpreted in the context of the method used.

Solution composition, pH, concentration, light exposure and storage time can alter Tyr-centered oxidation behavior. Prepare and store analytical solutions under conditions validated for the intended comparison.

Product Documents

MSDS - H-Gly-Tyr-Gly-OH (AS4105)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What is H-Gly-Tyr-Gly-OH?

It is Glycyl-tyrosyl-glycine; GYG, a defined research compound with sequence or structural identity Gly-Tyr-Gly.

Why is Gly-Tyr-Gly useful as a model?

The two glycine residues create a low-complexity environment around tyrosine for spectroscopy and Tyr-centered chemical-modification studies.

Is the tyrosine stereochemistry fully defined by the CAS alone?

Public records are not fully consistent, so confirm the lot-specific stereochemical designation when the experiment depends on it.

Research Use Only.