H-γ-Glu-Val-OH; CAS 2746-34-1 is γ-L-glutamyl-L-valine; gamma-Glu-Val, a gamma-glutamyl dipeptide in which the peptide bond is formed through the side-chain gamma-carboxyl group of glutamate rather than the conventional alpha-carboxyl group.

That connectivity makes gamma-glutamyl compounds analytically distinct from alpha-linked sequence isomers and relevant to metabolomics, gamma-glutamyl-cycle research and pathway-focused reference work.

Product Information

Gamma-Glutamyl Connectivity and Metabolomics

Gamma-glutamyl dipeptides are distinguished by side-chain amide connectivity at glutamate. They occur in metabolic and food-chemistry contexts and can be measured by LC-MS or related methods. Accurate annotation requires distinguishing gamma-linked species from alpha-linked isomers and confirming retention/mass behavior with an appropriate reference.

Why Gamma Linkage Matters

Gamma-glutamyl and alpha-glutamyl peptides can share residue composition while differing in bond position. Chromatographic or MS/MS methods should therefore be developed with connectivity in mind, especially when assigning biological or food-metabolomics peaks.

Procurement and QC Considerations

Confirm gamma-linkage, residue stereochemistry, CAS number and lot-specific purity. Alpha-linked glutamyl isomers can have similar formulae but different chromatographic and biological behavior.

For identity and purity documentation, review our peptide QC methods for HPLC and mass-spectrometric characterization principles.

For broader sequence or project work, see analytical peptide references.

Connectivity and Analytical Assignment

Gamma-linked glutamyl compounds can share residue composition with alpha-linked isomers while differing in bond position. Molecular mass alone is therefore insufficient for connectivity assignment; chromatographic behavior, structural documentation and, when needed, fragmentation data should be considered together.

For quantitative reference use, confirm the lot-specific purity or assay basis and the exact molecular form supplied. This is especially important when closely related positional isomers may be present in the analytical method.

Product Documents

MSDS - H-γ-Glu-Val-OH (AS4143)

The Safety Data Sheet provides product identification, laboratory handling guidance, exposure controls, transport information and safety information for research use.

Frequently Asked Questions

What is H-γ-Glu-Val-OH?

It is γ-L-glutamyl-L-valine; gamma-Glu-Val, a defined research compound with sequence or structural identity γ-Glu-Val.

Is this an alpha-linked glutamyl peptide?

No. The defining feature is gamma-glutamyl connectivity through the glutamate side-chain carboxyl group.

Why verify connectivity in metabolomics?

Alpha- and gamma-linked isomers can have similar mass but different retention, fragmentation and biological context.

Research Use Only.