$6892.00 - $20676.00
Fmoc-Tyr(PO(OBzl)OH)-OH (CAS 191348-16-0) is an Fmoc phosphotyrosine derivative with benzyl phosphate protection used in protected phosphopeptide building block. Its main synthetic value is phosphopeptide assembly with controlled phosphate protection.
Use when a protected phosphate is preferred during synthesis; verify deprotection compatibility with the full protecting-group scheme. For reproducible work, confirm identity and protection state against the COA before transferring conditions from a related analog.
Product Information
| Product Name | Fmoc-Tyr(PO(OBzl)OH)-OH |
| Catalog No. | AS4238 |
| CAS No. | 191348-16-0 |
| Molecular Formula | C31H28NO8P |
| Molecular Weight | 573.53 g/mol |
| Compound Type | Fmoc phosphotyrosine derivative with benzyl phosphate protection |
| Primary Research Use | Protected phosphopeptide building block |
Use in Site-Defined Phosphopeptides
Fmoc-Tyr(PO(OBzl)OH)-OH enables direct introduction of a phosphotyrosine-derived residue during peptide assembly. This supports preparation of defined phosphopeptides for recognition, binding and signaling studies without relying on post-synthetic enzymatic phosphorylation.
Phosphate Protection Strategy
The phosphate protection state affects polarity, coupling behavior and cleavage planning. A protected phosphate can simplify chain assembly, whereas a free or partially protected phosphate changes handling and may require additional attention to solubility and counterions.
Selection and QC
Confirm the exact phosphotyrosine protection pattern, stereochemistry, CAS and mass contribution before sequence calculation. For analytical work, phosphate-state identity is as important as nominal peptide purity.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-Tyr(PO(OBzl)OH)-OH (AS4238)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is the main application of this product?
It is used to introduce a defined phosphotyrosine-derived residue into a synthetic peptide.
Why does phosphate protection matter?
Protection changes polarity, coupling behavior and the conditions needed to reveal the final phosphate.
Can it replace unmodified Fmoc-Tyr-OH?
Only when the target peptide is designed to contain the phosphorylated or protected-phosphorylated tyrosine state.