Fmoc-(R)-2-amino-3-hydroxy-3-methyl butanoic acid (CAS 884880-39-1) is an Fmoc-protected noncanonical hydroxy amino-acid building block. Its β-hydroxy and β-methyl substitution pattern introduces defined steric and conformational features that distinguish it from standard amino-acid residues.

Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.

Product Information

Residue Design and Application

This building block is relevant when a target peptide or peptidomimetic requires the corresponding stereodefined β-hydroxy/β-methyl amino-acid motif. Its synthetic value derives from its stereochemistry and side-chain substitution pattern rather than from aromatic functionality.

Protection Strategy

The protecting group controls which functionality remains available during coupling and which cleavage chemistry is required later. Check the complete protection scheme before substituting this material for a related amino acid.

Sequence-Level Decision

Use this derivative when its side chain, backbone spacing or stereochemistry is part of the design hypothesis. For routine sequences, the corresponding standard residue is usually the simpler choice.

Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.

Product Documents

MSDS - Fmoc-(R)-2-amino-3-hydroxy-3-methyl butanoic acid (AS4283)

The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

Why does the exact derivative matter?

Fmoc-(R)-2-amino-3-hydroxy-3-methyl butanoic acid is selected for its defined functional groups and protection pattern; related forms can require different coupling or deprotection conditions.

Can a close analog replace Fmoc-(R)-2-amino-3-hydroxy-3-methyl butanoic acid?

Not safely by name alone. For Fmoc-(R)-2-amino-3-hydroxy-3-methyl butanoic acid, compare stereochemistry, protecting groups, salt/ester form and the intended downstream transformation.

What should procurement verify?

Match the product to CAS 884880-39-1 and the lot-specific COA rather than relying only on a shorthand chemical name.

Research Use Only.