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Fmoc-L-Propargylglycine (CAS 198561-07-8) is an Fmoc-protected alkyne amino-acid building block used in peptide installation of a terminal alkyne handle. Its main synthetic value is CuAAC conjugation, labeling and post-synthetic derivatization.
Use when the peptide requires a compact alkyne handle; protect the alkyne-compatible route from conditions that could consume or reduce the handle. The most relevant purchasing decision is whether this exact derivative removes a known synthetic constraint in the planned sequence or small-molecule route.
Product Information
| Product Name | Fmoc-L-Propargylglycine |
| Catalog No. | AS4242 |
| CAS No. | 198561-07-8 |
| Molecular Formula | C20H17NO4 |
| Molecular Weight | 335.35 g/mol |
| Compound Type | Fmoc-protected alkyne amino-acid building block |
| Primary Research Use | Peptide installation of a terminal alkyne handle |
Functional Handle in Peptide Synthesis
Fmoc-L-Propargylglycine carries a terminal alkyne while retaining a peptide-compatible protected amino-acid framework. This enables a reactive handle to be placed at a defined residue position during sequence assembly.
Post-Synthetic Derivatization
After peptide synthesis, the installed handle can support CuAAC or other alkyne-selective conjugation. The downstream conjugation strategy should be chosen with the complete peptide sequence, solvent compatibility and other reactive groups in mind.
Selection and Handling
Confirm the location and type of the reactive handle rather than treating all click-capable amino acids as equivalent. Light, reducing conditions, metals or nucleophiles can affect some functional groups differently.
Related options are grouped under unusual amino acid range. For broader route support, see advanced peptide building blocks.
Product Documents
MSDS - Fmoc-L-Propargylglycine (AS4242)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What functional handle does this building block introduce?
It introduces the azide or alkyne handle encoded in the product structure at a defined residue position.
Can the handle be used after peptide synthesis?
Yes, provided the synthesis and cleavage conditions preserve the reactive group.
Why is exact handle identity important?
Aryl azides, alkyl azides and terminal alkynes can have different stability and downstream reaction behavior.