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Fmoc-Gly-Gly-Phe-OtBu is a protected Gly-Gly-Phe tripeptide with an Fmoc-protected N-terminus and a tert-butyl ester on the C-terminal Phe carboxyl.
Because the C-terminus is protected, this is an intermediate for controlled fragment chemistry rather than a free-acid fragment ready for immediate C-terminal coupling.
Product Information
| Product Name | Fmoc-Gly-Gly-Phe-OtBu |
| Catalog No. | AS4163 |
| CAS No. | 236426-37-2 |
| Molecular Formula | C32H35N3O6 |
| Molecular Weight | 557.65 g/mol |
| Material / Building Block Type | Fmoc-Gly-Gly-Phe tripeptide C-terminal tert-butyl ester |
| Primary Applications | Protected Gly-Gly-Phe fragment synthesis; linker/cleavable-motif research; convergent peptide assembly; solution-phase intermediate chemistry |
Application Scope in Protected Fragment Synthesis
The Gly-Gly-Phe motif can be used in linker, peptide and conjugate research where a short flexible Gly segment leads into an aromatic residue. Preassembly fixes sequence order and can simplify repeated-motif route development.
C-Terminal Protection Changes the Coupling Plan
OtBu blocks the terminal carboxyl until acid-mediated deprotection. This can be useful when the fragment must first be manipulated from the N-terminus or carried through another reaction without exposing the carboxyl.
Procurement and QC
Confirm CAS 236426-37-2, C32H35N3O6, MW 557.65 g/mol, exact Gly-Gly-Phe sequence, N-Fmoc and C-terminal OtBu. Do not treat it as the corresponding free-acid tripeptide.
Select this reagent when the protected C-terminus is intentional; otherwise a free-acid fragment may provide a shorter route.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is the C-terminal Phe carboxyl free?
No. It is protected as a tert-butyl ester.
What does the fragment contain?
Gly-Gly-Phe in that sequence order.
When is the protected C-terminus useful?
When the fragment must undergo other chemistry before its terminal carboxyl is exposed.
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