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| Product Name | Fmoc-Arg(Pbf)-OH |
|---|---|
| Synonyms | Nα-Fmoc-Nω-Pbf-L-arginine; Nα-Fmoc-Nω-(2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl)-L-arginine |
| Catalog No. | AS2484 |
| CAS Number | 154445-77-9 |
| Molecular Formula | C34H40N4O7S |
| Molecular Weight | 648.77 g/mol |
| SMILES | Cc1c(C)c(c(C)c2CC(C)(C)Oc12)S(=O)(=O)NC(=N)NCCCC@HC(O)=O |
| Storage Temperature | Cool, dry place (≤25°C) |
| Appearance | White to off-white powder |
| Specific Rotation | -4.5° ± 1.5° (C=4 in DMF) |
| Functional Groups | Fmoc-protected α-amino group; Pbf-protected guanidino side chain; carboxylic acid |
| Primary Application | Fmoc solid-phase peptide synthesis (SPPS) |
Product Overview
Fmoc-Arg(Pbf)-OH (CAS 154445-77-9; catalog AS2484) is an Fmoc-protected L-arginine building block with Pbf protection on the guanidino side chain. It is used to introduce arginine during Fmoc solid-phase peptide synthesis. The free alpha-carboxyl group participates in coupling, while the two protecting groups control access to the alpha-amino and guanidino functionalities.
Quality Specifications and Ordering
Purity: Alan Scientific supplies Fmoc-Arg(Pbf)-OH at >99% purity.
Catalog pack sizes: 25 g, 100 g, 500 g, and 1 kg.
Quality documentation: See Product Documents below for lot-specific COA request details. Review the analytical methods and results reported for the supplied batch.
Quotation: Email [email protected] with AS2484, the pack size, total quantity, delivery destination, and required date. Confirm availability and dispatch lead time before ordering.
For Arg-rich sequences, distinguish the incoming building-block specification from the acceptance criteria for the fully deprotected peptide. State any additional impurity or stereochemical requirements in the inquiry.
Pbf Protection in Fmoc-SPPS
The Pbf group is retained during routine basic Fmoc-deprotection cycles and is removed during an appropriate final acidic deprotection. This permits arginine incorporation without leaving the guanidino group unprotected throughout chain assembly.
Complete Pbf removal should be evaluated for the actual sequence, especially when several arginine residues or other cleavage-sensitive residues are present. Cleavage conditions, scavenger selection, and analytical assessment belong to the complete peptide process; the building block alone does not guarantee a fully deprotected final product.
For compatibility with other protected residues in the same sequence, consult the Fmoc amino acid protecting-group guide. It explains protection choices across the complete peptide route.
Arginine-Containing Peptide Applications
Applications include research peptide libraries, arginine-substitution studies, and sequences designed to investigate charge-dependent molecular interactions. Arginine residues in the deprotected peptide can contribute cationic character, but that behavior should not be attributed directly to this protected synthesis reagent.
For Arg-rich sequences, consider the whole construct when planning synthesis and purification. Residue count, sequence length, other hydrophobic residues, and terminal modifications all influence the final material. Cell uptake, target binding, and biological activity require experimental evaluation rather than prediction from arginine content alone.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage, and safety assessment.
Certificates of Analysis are batch-specific. Please contact us to request a COA, and we will provide it by email.
Frequently Asked Questions
Can I request 500 g or 1 kg of Fmoc-Arg(Pbf)-OH for process-development work?
Yes. Both 500 g and 1 kg are catalog pack sizes, alongside 25 g and 100 g. Quote AS2484, the total quantity, delivery destination, required date, and any additional analytical requirements. Confirm availability and dispatch lead time before placing the order.
Is Pbf removed during each Fmoc-deprotection cycle?
No. Pbf is intended to remain during routine basic Fmoc removal and to be removed during a compatible final acidic deprotection.
Is the same cleavage treatment suitable for every Arg-rich peptide?
Not necessarily. Complete deprotection and unwanted reactions depend on the sequence and processing conditions, so the final material needs appropriate analytical assessment.
Research Use Only
For research use only. Not for human or veterinary use.