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Z-Phe-Leu-OH (CAS 4313-73-9) is an N-protected peptide fragment used in fragment coupling and convergent peptide assembly. Its main synthetic value is fragment condensation, sequence assembly and synthetic route comparison.
Consider fragment use when a preformed sequence block improves route control versus fully stepwise assembly; coupling-site epimerization and solubility still require evaluation. Its value is route-specific, so selection should follow the intended transformation rather than the broad category label.
Product Information
| Product Name | Z-Phe-Leu-OH |
| Catalog No. | AS4271 |
| CAS No. | 4313-73-9 |
| Molecular Formula | C23H28N2O5 |
| Molecular Weight | 412.48 g/mol |
| Compound Type | N-protected peptide fragment |
| Primary Research Use | Fragment coupling and convergent peptide assembly |
Preformed Sequence Fragment
Z-Phe-Leu-OH provides a defined protected peptide segment rather than a single amino-acid residue. A preformed fragment can reduce the number of sequential couplings required in a convergent route.
Fragment Coupling Decision
Fragment use is most valuable when it improves route control, purification or access to a difficult sequence block. The advantage must be weighed against fragment solubility, activation efficiency and the risk of epimerization at the coupling junction.
Protection and Downstream Assembly
The N-terminal protecting group preserves sequence directionality while the free carboxyl terminus remains available for further coupling. Confirm that the fragment protection pattern matches the planned global deprotection strategy.
Related options are grouped under specialty peptide building blocks. For broader route support, see sequence-specific synthesis support.
Product Documents
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Frequently Asked Questions
Is this a single amino-acid building block?
No. It is a protected peptide fragment containing multiple residues.
When is fragment coupling useful?
It can be useful in convergent synthesis when a preformed sequence block improves route control or avoids repeated stepwise assembly.
What should be checked before fragment coupling?
Evaluate fragment solubility, terminal protection, activation conditions and epimerization risk at the coupling site.