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Fmoc-Cys(S-CH2COOtBu)-OH, (R) (CAS 269730-62-3) is a Protected amino-acid / peptidomimetic building block selected for a sulfur-containing residue with protection selected to manage thiol/thioether reactivity during synthesis. This positions it within peptide, peptidomimetic and medicinal-chemistry synthesis.
Use when the target structure specifically requires this residue or protection pattern; confirm stereochemistry and deprotection compatibility before substituting it into an established route. Before substitution into an established synthesis, compare stereochemistry, protecting-group orthogonality and downstream deprotection requirements.
Product Information
| Product Name | Fmoc-Cys(S-CH2COOtBu)-OH, (R) |
| Catalog No. | AS4289 |
| CAS No. | 269730-62-3 |
| Molecular Formula | C24H27NO6S |
| Molecular Weight | 457.54 g/mol |
| Compound Type | Protected amino-acid / peptidomimetic building block |
| Primary Research Use | Peptide, peptidomimetic and medicinal-chemistry synthesis |
Functional Role of the Residue
Fmoc-Cys(S-CH2COOtBu)-OH, (R) provides a sulfur-containing residue with protection selected to manage thiol/thioether reactivity during synthesis. In a peptide or small-molecule route, this feature should be introduced deliberately because it can change both synthetic behavior and final molecular properties.
Route Compatibility
Evaluate coupling conditions and deprotection orthogonality with the neighboring residues and other protecting groups already present. The most reliable route is the one designed around the full protection pattern, not an isolated building block.
Browse the unusual residue building blocks for related structures. Complex sequence work can also use specialty peptide building blocks.
Product Documents
MSDS - Fmoc-Cys(S-CH2COOtBu)-OH, (R) (AS4289)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is Fmoc-Cys(S-CH2COOtBu)-OH, (R) mainly used for?
Peptide, peptidomimetic and medicinal-chemistry synthesis.
What is the critical identity check?
Confirm CAS 269730-62-3, stereochemistry or positional isomer where applicable, and the complete protection state.
What documentation should be matched to the lot?
Use the COA to confirm assay and analytical identity; the nominal formula is C24H27NO6S with molecular weight 457.54 g/mol.