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Fmoc-Ala-Trp-OH is a preassembled Fmoc-protected Ala-Trp dipeptide with a free C-terminal tryptophan carboxyl group.
The fragment combines a compact Ala residue with an indole-containing Trp residue and is useful when the Ala-Trp sequence is fixed across a series or when convergent fragment assembly is preferable to two separate coupling cycles.
Product Information
| Product Name | Fmoc-Ala-Trp-OH |
| Catalog No. | AS4173 |
| CAS No. | 255381-12-5 |
| Molecular Formula | C29H27N3O5 |
| Molecular Weight | 497.55 g/mol |
| Material / Building Block Type | Fmoc-protected L-Ala-L-Trp dipeptide fragment |
| Primary Applications | Convergent peptide synthesis; Ala-Trp motif installation; aromatic/hydrophobic fragment assembly; Trp-containing peptide libraries |
Application Scope in Fragment Assembly
A preformed Ala-Trp fragment can reduce one coupling step and provide a separately characterized aromatic sequence unit for analog libraries, longer peptide synthesis and selected solution-phase routes.
Tryptophan Changes Solubility and Chromatography
The indole side chain increases aromaticity and hydrophobic retention. In longer sequences, Trp-containing fragments can influence resin swelling, crude solubility and RP-HPLC separation even when coupling itself is efficient.
Identity and QC
Confirm CAS 255381-12-5, C29H27N3O5, MW 497.55 g/mol, sequence direction Ala-Trp and L stereochemistry. Sequence order and stereochemistry are not established by mass alone.
For sequences with several aromatic residues or fragment-coupling steps, Alan Scientific can evaluate the route through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is Ala-Trp the same as Trp-Ala?
No. Sequence order defines a different molecule.
Why use a preformed dipeptide?
It reduces one downstream coupling step and fixes sequence identity before fragment incorporation.
Does Trp affect purification?
It can increase hydrophobic retention and influence crude peptide solubility.
Related Technical Resources
Review SPPS and fragment assembly fundamentals