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Fmoc-Ala-Ala-Asn(Trt)-Gly-OH is a preassembled protected tetrapeptide with the sequence Ala-Ala-Asn-Gly. The N-terminus is Fmoc-protected, the Asn side-chain amide is Trt-protected, and the C-terminal Gly carboxyl group remains available for further coupling.
Its value is route control rather than simply 'four residues at once.' When the same motif appears in several analogs or a long sequence is being assembled convergently, a verified fragment can reduce the number of downstream coupling cycles described in the SPPS practical guide.
Product Information
| Product Name | Fmoc-Ala-Ala-Asn(Trt)-Gly-OH |
| Catalog No. | AS4058 |
| CAS No. | Not confirmed |
| Molecular Formula | C46H45N5O8 |
| Molecular Weight | 795.89 g/mol |
| Building Block Type | Fmoc-protected Ala-Ala-Asn(Trt)-Gly tetrapeptide fragment |
| Primary Applications | Protected fragment coupling; convergent peptide synthesis; Ala-Ala-Asn-Gly motif installation; difficult sequence assembly |
Sequence Order Is an Identity Parameter
Ala-Ala-Asn-Gly is not interchangeable with another permutation containing the same residues. Fragment procurement should therefore confirm sequence order, N-terminal Fmoc, Asn(Trt), and the free C-terminal carboxyl group.
Why Protect Asn with Trt
Trt protection masks the Asn side-chain amide nitrogen during synthesis and helps limit side reactions under peptide-coupling conditions. It is removed during final strong-acid deprotection when compatible with the complete route.
When a Tetrapeptide Fragment Can Be Useful
Preassembled fragments are most attractive in convergent synthesis, repeated motif construction, or sequences where stepwise assembly becomes inefficient. For a short routine peptide, direct residue-by-residue SPPS may still be simpler and more economical.
Procurement and QC
No reliable CAS number has been confirmed for this protected tetrapeptide fragment. Identity should therefore be verified by the Ala-Ala-Asn(Trt)-Gly sequence, protection pattern, molecular formula, molecular weight and lot-specific LC-MS/HPLC data.
For long or fragment-based targets, we can compare direct SPPS with convergent assembly through custom peptide synthesis.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Fmoc-Ala-Ala-Asn(Trt)-Gly-OH MSDS
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Does AS4058 have a confirmed CAS number?
No reliable CAS number has been confirmed. Sequence, protection state and lot-specific analytical data should be used for identity verification.
Which side chain is Trt-protected?
The Asn side-chain amide is protected as Asn(Trt).
Why use a tetrapeptide fragment?
It can reduce downstream coupling cycles and provide a separately characterized sequence segment.
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