Fmoc-2-Me-Ser-OH: identity and synthesis considerations
Fmoc-2-Me-Ser-OH is an N-Fmoc-protected alpha-methylserine derivative with a free carboxylic acid and unprotected hydroxymethyl side chain. The methyl group is on the alpha carbon, not nitrogen or oxygen.
| Catalog No. | AS2143 |
|---|---|
| CAS No. | 207117-28-0 |
| Molecular formula | C19H19NO5 |
| Molecular weight | 341.36 g/mol |
Free hydroxyl
Unlike Fmoc-Ser(tBu)-OH, this product has no tBu-protected side-chain oxygen. Select coupling and derivatization conditions that tolerate the free alcohol.
Alpha-methyl center
Assess incorporation and the next coupling after Fmoc removal separately. Alpha methylation changes steric demand but does not by itself establish peptide stability or activity.
Product Documents
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is this O-methylserine?
No. The side-chain hydroxyl remains free.
Does it have tBu protection?
No.
Research Use Only. Not for human or veterinary use.