α-Conotoxin GS is a neurotoxic peptide isolated from the venom of the cone snail Conus striatus, specifically targeting nicotinic acetylcholine receptors (nAChRs). This peptide acts as a competitive antagonist, binding to the ligand-binding sites of muscle-type (α1β1γδ/ε) and neuronal nAChR subtypes to block acetylcholine-mediated receptor activation. By disrupting cholinergic signaling, α-Conotoxin GS inhibits neuromuscular transmission and neuronal communication, playing a critical role in the snail’s predatory mechanism. In research, it serves as a valuable tool to investigate the structural and functional diversity of nAChRs, particularly in understanding receptor subtypes involved in pain processing, muscle function, and neurological disorders. Its high specificity and affinity for nAChRs make it a promising candidate for developing therapeutic agents targeting nAChR-related conditions, such as chronic pain or autoimmune diseases, while offering insights into the evolutionary specialization of venom peptides for precise molecular targeting.

Chemical Formula: C139H232N52O47S7

Molecular Weight: 3624.11

Sequence: Ala-Cys-Ser-Gly-Arg-Gly-Ser-Arg-Cys-Hyp-Hyp-Gln-Cys-Cys-Met-Gly-Leu-Arg-Cys-Gly-Arg-Gly-Asn-Pro-Gln-Lys-Cys-Ile-Gly-Ala-His-Gla-Asp-Val

Purity: From crude to 98%

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