Caspase 1 Substrate 1 (ICE), chromogenic is a specialized reagent for detecting and measuring the activity of caspase - 1, also known as interleukin - 1β - converting enzyme (ICE). This chromogenic substrate is designed with a specific peptide sequence that caspase - 1 can recognize and cleave. Once cleaved, it undergoes a color change reaction. Scientists can utilize this color change to quantitatively analyze caspase - 1 activity in various biological samples. This is significant because caspase - 1 plays a central role in the inflammatory response and programmed cell death pathways. The use of this substrate facilitates research on inflammation - related diseases, such as autoimmune disorders and neurodegenerative diseases, as well as drug discovery targeting caspase - 1 regulation.

Chemical Formula: C217H322N58O60S

Molecular Weight: 4767.47

Sequence: Ac-Tyr-Glu-Val-Asp-pNA

Purity: From crude to 98%

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Research Use Only