$271.00 - $271.00
Canine Orexin B is a 28-residue amidated orexin-family peptide from dog. Its primary sequence is highly conserved relative to human and rodent Orexin B while containing a distinct combination of species-specific residues.
Product Information
| Property | Specification |
|---|---|
| Sequence | Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH₂ |
| One-Letter Sequence | RPGPPGLQGRLQRLLQASGNHAAGILTM-NH₂ |
| Peptide Length | 28 amino-acid residues |
| Molecular Formula | C125H214N44O34S |
| Molecular Weight | Approximately 2909.44 Da |
| C-Terminus | Met-NH₂ |
| Species | Canine |
A Useful Natural Sequence Comparison
Canine Orexin B differs from human Orexin B at position 2 while retaining the human-type residue at the region where rodent Orexin B contains another substitution.
It therefore provides a useful natural intermediate for comparative sequence–activity studies involving human, canine and rodent ligands.
Species Context Matters
Differences of only one or two residues can alter peptide conformation, receptor potency or proteolytic behavior without changing the broad receptor class. We recommend using the exact species sequence when canine tissues or receptor constructs are investigated.
Research Applications
Canine Orexin B can support comparative receptor signaling, veterinary neuroendocrine studies, sleep-wake biology and natural-sequence SAR.
Species-specific analogs can also be evaluated through Chemical Peptide Synthesis.