Boc-Nva-OHdicyclohexylaminesalt is the dicyclohexylammonium (DCHA) salt of N-Boc-L-norvaline, a non-natural amino-acid derivative used in peptide, peptidomimetic and medicinal-chemistry synthesis. Norvaline has a straight-chain n-propyl side chain, making it a useful hydrophobic SAR residue when researchers want to change side-chain branching without introducing aromatic or charged functionality.

The DCHA form is a 1:1 amine salt used as an isolable protected-amino-acid form. It should not be interpreted as the free Boc-Nva-OH molecular formula alone; procurement and stoichiometric calculations must account for the dicyclohexylammonium component.

Product Information

Why Norvaline Is a Useful Non-Natural Residue

L-Norvaline is an unbranched aliphatic amino acid. Compared with valine, which is beta-branched, norvaline redistributes the same general hydrophobic character into a more linear side chain. This makes Nva useful in stereochemical and hydrophobicity-focused SAR, where a researcher wants to probe how side-chain shape and branching affect peptide conformation or target recognition.

The effect of Val-to-Nva or other residue substitutions cannot be predicted from hydrophobicity alone. Binding, proteolysis, membrane interaction and conformational preferences should be measured in the final peptide.

Why the DCHA Salt Matters

The dicyclohexylammonium salt changes the supplied material's composition and molecular weight. For reaction planning, researchers should distinguish Boc-Nva-OH.DCHA from free Boc-Nva-OH and should use the molecular weight of the supplied salt when calculating equivalents.

The salt form may be converted or used according to the specific synthetic route. The DCHA component is not intended to remain as a structural element of the final peptide.

Application Scope

Boc-Nva-OH.DCHA is suitable for non-natural peptide synthesis, peptidomimetic design, protected-fragment chemistry and medicinal-chemistry programs exploring linear aliphatic side chains. Norvaline-containing intermediates also appear in protease- and proteasome-inhibitor synthetic chemistry, illustrating its broader use in peptide-inspired small-molecule design.

The material is a synthetic building block rather than a direct in vitro or in vivo assay reagent. Final Nva-containing peptides or peptidomimetics may be evaluated in biochemical, cellular or pharmacology studies after full synthesis and purification.

Data and Procurement Note

For this product, the combined salt identity is important. Public chemical records support CAS 67861-96-5, C₂₂H₄₂N₂O₄ and MW approximately 398.58-398.59 for Boc-L-Nva-OH.DCHA. A component-style formula such as “Boc-Nva-OH; DCHA” can describe the salt conceptually, but the combined formula is clearer for search, procurement and analytical matching.

Lot-specific COA should confirm identity, purity and salt form before use.

Product Documents

A Material Safety Data Sheet (MSDS) is available for this product to support laboratory handling, storage and safety assessment.

📎 MSDS_Boc-Nva-OHdicyclohexylaminesalt_AS4050.pdf

Frequently Asked Questions

What does DCHA mean in Boc-Nva-OH.DCHA?

DCHA means dicyclohexylamine/dicyclohexylammonium. The supplied material is the dicyclohexylammonium salt of Boc-L-norvaline.

Is Boc-Nva-OH.DCHA the same as free Boc-Nva-OH?

No. They contain the same protected amino-acid moiety but differ in salt state, composition and molecular weight.

Why use norvaline in peptide SAR?

Norvaline provides an unbranched hydrophobic side chain and can help probe the effect of side-chain branching and shape relative to residues such as valine.

Related Technical Resources

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For sequence-specific synthesis, protected-fragment assembly and modified peptide projects, see our Chemical Peptide Synthesis service.

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