Biotin-[Tyr0]-Orexin B, mouse, rat is a synthetic analog of Orexin B (Hypocretin-2) from mouse and rat sources, incorporating a biotin tag at the Tyr0 position. This modification enables detection, purification, or immobilization in biochemical studies while retaining bioactivity. The analog binds to Orexin 1 (OX1) and Orexin 2 (OX2) receptors, influencing arousal, appetite regulation, energy homeostasis, and stress responses. In pharmacological research, it serves as a tool to investigate Orexin receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for obesity, insomnia, and psychiatric disorders. The biotinylation allows for targeted labeling and interaction studies, enhancing its utility in receptor binding assays, imaging, and drug discovery focused on Orexin signaling pathways.

Chemical Formula: C145H238N48O38S2

Molecular Weight: 3325.90

Sequence: Biotin-Tyr-Arg-Pro-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Ala-Asn-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Purity: From crude to 98%

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