Angiotensin I-Converting Enzyme Substrate refers to angiotensin I, a decapeptide that serves as the natural substrate for angiotensin-converting enzyme (ACE). Generated by renin-mediated cleavage of angiotensinogen in the renin-angiotensin system (RAS), angiotensin I is enzymatically processed by ACE to release the bioactive octapeptide angiotensin II (via removal of a C-terminal histidine-leucine dipeptide). This conversion is critical for activating vasoconstrictive, sodium-retaining, and pro-inflammatory pathways that regulate blood pressure, fluid balance, and cardiovascular homeostasis. In pharmacological research, the substrate acts as a tool to investigate ACE specificity, enzyme kinetics, and the development of ACE inhibitors—drugs widely used to treat hypertension, heart failure, and diabetic nephropathy by blocking angiotensin II formation. Its role as a central intermediate in the RAS highlights its importance in both physiological regulation and therapeutic targeting of cardiovascular and renal disorders.

Chemical Formula: C24H27N3O5

Molecular Weight: 437.49

Sequence: Bz-Phe-Ala-Pro

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only