[Ala11,D-Leu15]-Orexin B (human) is a synthetic analog of human Orexin B (Hypocretin-2), featuring alanine (Ala) substitution at position 11 and D-leucine (D-Leu) at position 15. These modifications enhance resistance to enzymatic degradation and modulate binding affinity for Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Retaining bioactivity, it influences arousal, appetite regulation, energy homeostasis, and stress responses. In pharmacological research, this analog serves as a tool to investigate Orexin receptor activation mechanisms, structure-activity relationships, and explore therapeutic potential for obesity, insomnia, and psychiatric disorders. Its amino acid substitutions enable focused studies on receptor selectivity and peptide stability, offering insights into Orexin signaling pathways and drug development.

Chemical Formula: C120H206N44O35S

Molecular Weight: 2857.28

Sequence: Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-D-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2

Purity: From crude to 98%

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