SV40 Nuclear Transport Signal Peptide Analog is a synthetic or modified version of the natural Simian Virus 40 (SV40) nuclear transport signal peptide. The original SV40 signal peptide, a key component in the large T - antigen of SV40, is renowned for its ability to direct proteins to the cell nucleus. This analog mimics the function of the native peptide by interacting with cellular import machinery, specifically importin proteins in the cytoplasm. Once bound, the complex can traverse the nuclear pore complex, facilitating the entry of associated molecules into the nucleus. In research and biotechnological applications, these analogs are invaluable. They can be conjugated to various cargo molecules, such as therapeutic drugs, nucleic acids, or proteins of interest, enabling targeted delivery to the nucleus. This targeted approach is crucial for studies related to gene regulation, nuclear - based therapies, and understanding nuclear - cytoplasmic transport mechanisms, as it allows for controlled manipulation of substances within the nucleus.

Chemical Formula: C60H104N20O15S

Molecular Weight: 1377.68

Sequence: Cys-Gly-Tyr-Gly-Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly-Gly

Purity: From crude to 98%

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Research Use Only