SV40 NLS stands for Simian Virus 40 Nuclear Localization Signal. It is a short, highly conserved amino acid sequence found in the large T - antigen of the Simian Virus 40 (SV40). This sequence, typically consisting of a stretch of basic amino acids, plays a crucial role in directing proteins to the cell nucleus. The SV40 NLS interacts with specific importin proteins in the cytoplasm, which then facilitate the transport of the protein - NLS complex through the nuclear pore complex into the nucleus. In research, the SV40 NLS is widely used as a tool. Scientists attach it to proteins or other molecules of interest to ensure their delivery and accumulation in the nucleus. This is particularly useful in studies aiming to manipulate gene expression, study nuclear - related processes, or develop gene - based therapies, as it allows for precise targeting of substances to the site where DNA - related activities occur.

Chemical Formula: C42H81N15O9

Molecular Weight: 940.21

Sequence: Pro-Lys-Lys-Lys-Arg-Lys-Val-Gly

Purity: From crude to 98%

If there are no products available iwth the required purity and quantity, please inform us of your specifications and send an email to sales@alanscientific.com

Our representitives will respond within 24 hours

Research Use Only