Substance P (3-11), also known as Nona Substance P, is the nine-residue C-terminal fragment Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂. It lacks only the N-terminal Arg-Pro sequence while retaining Lys3 and the complete amidated C-terminal pharmacophore.

Compared with shorter SP fragments, SP(3-11) preserves more of the native peptide's charge distribution and backbone length. It is useful for systematic truncation studies, peptide-processing research and experiments examining how the first two residues contribute to Substance P recognition.

Product Information

Removal of Arg1-Pro2

SP(3-11) removes the first two residues of native Substance P but preserves Lys3. The truncation reduces the highly basic character of the extreme N-terminus while retaining the entire C-terminal receptor-interaction region.

This makes the fragment useful for determining whether observed differences arise from loss of N-terminal charge, reduced peptide length or altered peptide-processing susceptibility.

Research Applications

Substance P (3-11) can support truncation SAR, peptide metabolism studies, tachykinin receptor research and LC-MS/MS analysis of Substance P-derived fragments.

Frequently Asked Questions

What is removed from Substance P?

Arg1 and Pro2 are absent.

Does SP(3-11) retain Lys3?

Yes.

Is the C-terminal Met amidated?

Yes.

Research Use Only.