[Pyr6,Pro9]-Substance P (6-11) is a modified analog of the hexapeptide Substance P (6-11), incorporating pyroglutamic acid (Pyr) at position 6 and proline (Pro) at position 9. These substitutions enhance stability, resistance to enzymatic degradation, and binding affinity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor specificity, and explore therapeutic potential for analgesic and anti-inflammatory applications.

Chemical Formula: C39H53N7O7S

Molecular Weight: 763.98

Sequence: Pyr-Phe-Phe-Pro-Leu-Met-NH2

Purity: From crude to 98%

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Research Use Only