$485.71 - $1428.57
N-Benzoyl-L-leucine is an N-benzoylated L-leucine derivative with a free carboxylic acid. In peptide chemistry, its most distinctive value is its use in the Young test, a classical approach for comparing racemization during peptide-bond formation.
We see this product as a useful QC and process-development tool for peptide chemists. Its value is highest when a laboratory is selecting or validating coupling conditions for residues prone to racemization.
Product Information
| Product Name | N-Benzoyl-L-leucine |
| Catalog No. | AS4082 |
| CAS No. | 1466-83-7 |
| Molecular Formula | C13H17NO3 |
| Molecular Weight | 235.28 g/mol |
| Chemical Identity | N-Benzoyl-L-leucine; Bz-Leu-OH |
| Primary Applications | Peptide-coupling racemization studies, solution-phase synthesis and synthetic chemistry |
Why N-benzoyl-L-leucine is useful in the Young test
Racemization can occur during activation of a chiral amino-acid carboxyl group. The Young test uses a defined benzoylated amino-acid substrate so that coupling conditions can be compared by measuring formation of diastereomeric products. That makes the reagent relevant to method development rather than only to routine peptide assembly.
Using the reagent as a coupling benchmark
When comparing coupling reagents, bases or activation times, keep concentration, temperature and workup consistent so that observed epimerization reflects the chemistry being tested. Analytical resolution of the diastereomeric products is essential; total conversion alone does not report stereochemical integrity.
Procurement and QC Considerations
Confirm CAS 1466-83-7, the stated molecular formula and lot-specific analytical identity. Review the COA together with the MSDS when the material will be used in sequence-sensitive or process-development work.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
MSDS_AS4082_N-Benzoyl-L-leucine
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is N-benzoyl-L-leucine used for in peptide chemistry?
It is used in synthetic chemistry and is specifically associated with the Young test for evaluating racemization during peptide coupling.
Why is racemization important?
Epimerization changes stereochemistry without changing molecular formula, so a peptide can have the expected mass but the wrong stereochemical composition.
Is this an Fmoc-SPPS building block?
It is better treated as a benzoylated amino-acid derivative and racemization-test reagent than as a standard Fmoc-SPPS monomer.
Related Technical Resources
Browse related specialty peptide building blocks for protected amino acids, fragments and noncanonical synthesis intermediates.
For complete sequence work using this chemistry, see our peptide coupling and route-development support.