Melanotan II, MT-Ⅱ is a synthetic peptide analog of α-melanocyte-stimulating hormone (α-MSH), designed to activate melanocortin receptors—predominantly MC1R on melanocytes—to stimulate melanin production and induce skin pigmentation. This non-selective agonist mimics the natural tanning process by enhancing eumelanin synthesis, making it a subject of research for potential applications in photoprotection, treating pigmentation disorders like vitiligo, or as an artificial tanning agent. While studied for its ability to reduce UV-induced skin damage and promote a tan, Melanotan II is not approved for clinical use in most regions due to safety concerns, including risks of nausea, hypotension, and off-target effects on other melanocortin receptors. Its synthetic structure and melanogenic properties make it valuable in preclinical investigations of pigmentation biology and receptor signaling, though its use remains experimental and tightly regulated due to unresolved safety profiles and lack of medical endorsement.

Chemical Formula: C50H69N15O9

Molecular Weight: 1024.20

Sequence: Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-NH2-(Lactambridge:Asp2-Lys7)

Purity: From crude to 98%

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