LL-37 pentamide is a synthetic, five-amino acid peptide derived from the human antimicrobial peptide LL-37, featuring a C-terminal amide modification to enhance stability and membrane interaction. This truncated variant retains key structural elements of the native LL-37, such as cationic residues, which enable it to disrupt microbial membranes and modulate immune responses, though with potentially altered activity compared to the full-length peptide. In research, LL-37 pentamide is used to investigate the minimal functional domains of LL-37 responsible for antimicrobial or immunomodulatory effects, serving as a model to study peptide-lipid interactions, cytotoxicity, and mechanism of action against bacteria, fungi, or viruses. Its simplified structure facilitates detailed biophysical studies and the development of novel antimicrobial agents with optimized properties, while also offering insights into the role of specific amino acid sequences in host defense and inflammatory processes.

Chemical Formula: C208H343N65O48

Molecular Weight: 4522.46

Sequence: Leu-Leu-Gly-Asn-Phe-Phe-Arg-Lys-Ser-Lys-Gln-Lys-Ile-Gly-Lys-Gln-Phe-Lys-Arg-Ile-Val-Gln-Arg-Ile-Lys-Asn-Phe-Phe-Arg-Asn-Leu-Val-Pro-Arg-Thr-Gln-Ser

Purity: From crude to 98%

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Research Use Only