Interleukin-6 Receptor (partial) is a fragment of the cell surface glycoprotein IL-6R, which mediates signaling by the cytokine interleukin-6 (IL-6). Typically encompassing the extracellular ligand-binding domain (e.g., the Sushi domain and cytokine receptor homology module), this partial receptor retains the ability to interact with IL-6 and initiate downstream signaling through association with the common signal transducer gp130. In physiological contexts, IL-6R signaling drives immune responses, inflammation, hematopoiesis, and cell proliferation, while dysregulation is linked to autoimmune diseases, cancer, and metabolic disorders. In pharmacological research, the partial receptor serves as a tool to investigate ligand-receptor interactions, receptor dimerization mechanisms, and the development of antagonists (e.g., tocilizumab, an anti-IL-6R antibody used in rheumatoid arthritis). Its use facilitates studies on JAK-STAT and MAPK pathway activation, structure-activity relationships, and therapeutic strategies targeting IL-6-mediated inflammatory or proliferative diseases.

Chemical Formula: C51H85N13O21

Molecular Weight: 1216.32

Sequence: Thr-Ser-Leu-Pro-Val-Gln-Asp-Ser-Ser-Ser-Val-Pro

Purity: From crude to 98%

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Research Use Only