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H-N-Me-Ser-OMe.HCl is independently indexed as methyl N-methyl-L-serinate hydrochloride. The backbone nitrogen is N-methylated, the carboxyl group is protected as a methyl ester, the serine hydroxyl remains free, and the amine is supplied as the HCl salt.
This material is an intermediate rather than a direct Fmoc-SPPS monomer. It can be converted into other protected N-methylserine derivatives for the noncanonical amino-acid space.
Product Information
| Product Name | H-N-Me-Ser-OMe.HCl |
| Catalog No. | AS4191 |
| CAS No. | 207570-19-2 |
| Molecular Formula | C5H12ClNO3 |
| Molecular Weight | 169.61 g/mol |
| Building Block Type | N-methyl-L-serine methyl ester hydrochloride |
| Primary Applications | N-methyl amino-acid derivatization; protected intermediate synthesis; peptide-building-block preparation; medicinal chemistry |
Four Features Must Be Read Together
N-methylation, methyl-ester protection, a free hydroxyl, and HCl salt form all affect downstream chemistry. Omitting any one of these details can lead to incorrect reagent-equivalent calculations or protection planning.
The Methyl Ester Blocks Routine Peptide Coupling
The carboxyl group is not available as a free acid. Hydrolysis or another planned transformation is required before the residue can be used as a conventional carboxyl-coupling monomer.
The Free Serine Hydroxyl Can React
Because the side-chain OH is not protected, downstream acylation or derivatization chemistry should be selected with O-reactivity in mind. This can be useful when the hydroxyl is the intended modification site.
Procurement and QC
Confirm CAS 207570-19-2, C5H12ClNO3, MW 169.61 g/mol, L configuration, N-methyl substitution, methyl ester, and hydrochloride salt. Major supplier safety data list H302, H315, and H319.
If this intermediate is being converted into a sequence-ready N-methylserine building block, the final protecting-group state can be planned through custom peptide synthesis support.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
Is the carboxyl group free?
No. It is protected as a methyl ester.
Is the serine hydroxyl protected?
No. The side-chain hydroxyl remains free.
Does the molecular weight include HCl?
Yes. The listed formula and MW correspond to the hydrochloride salt.
Related Technical Resources
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