Fmoc Aminotriacid (CAS 798576-99-5) is the Fmoc-protected scaffold 4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-carboxyethyl)heptanedioic acid. Its defining feature is the combination of one Fmoc-protected amino group with three carboxylic-acid handles.

This is a multivalent scaffold rather than a conventional amino-acid monomer. The three acids can be activated and derivatized to build branched or multivalent constructs, while Fmoc provides a temporary protecting group on the central amino function.

Product Information

Three Carboxyl Handles Change the Synthetic Problem

With a monoacid building block, activation is usually a single-site event. Here, partial activation, statistical substitution and incomplete functionalization can generate families of closely related products. We consider stoichiometry and analytical strategy central to route design: “high purity starting material” does not by itself guarantee a single substitution state after multivalent coupling.

Use as a Multivalent Peptide or Conjugation Scaffold

Triacid scaffolds of this type have been used in multivalent ligand and branched-conjugate research because several peptide or functional arms can be presented from one core. Alan's peptide synthesis capabilities for branched and multivalent constructs include project-specific modified peptide and multiple-antigen-peptide workflows; feasibility depends on the arm sequence, coupling chemistry and desired substitution level.

Fmoc Is Protection, Not the Main Functional Readout

The fluorenyl group is present as an Fmoc protecting group. We do not recommend describing Fmoc Aminotriacid primarily as a fluorescent labeling reagent. The higher-value chemical function is the triacid branching platform. Our discussion of specialty and noncanonical building blocks in peptide design provides broader context for why multi-functional scaffolds can expand peptide architecture beyond a linear chain.

Procurement and QC Considerations

Confirm CAS 798576-99-5, formula C25H27NO8, MW 469.48 g/mol and the presence of three free carboxyl groups. For downstream multivalent chemistry, water content, residual protecting-group variants and chromatographic purity can affect activation stoichiometry. We recommend defining the desired degree of substitution and the analytical method before scale-up.

For route planning, other specialty peptide building blocks can be useful when the multivalent core must be combined with protected linkers, amino acids or short peptide fragments.

Product Documents

A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.

Fmoc Aminotriacid MSDS

Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.

Frequently Asked Questions

What makes Fmoc Aminotriacid different from a normal amino acid?

It has three carboxylic-acid handles around one Fmoc-protected amino-bearing core, making it a multivalent scaffold rather than a standard peptide monomer.

Can all three carboxyl groups be functionalized?

They can serve as coupling handles, but the practical substitution pattern depends on activation chemistry, stoichiometry, sterics and the target construct.

Is Fmoc Aminotriacid mainly a fluorescent label?

No. Fmoc is used primarily as an amino-protecting group; the key synthetic feature is the triacid branching architecture.

Related Technical Resources

For linear building-block chemistry before moving into multivalent designs, see the practical peptide-synthesis guide. The specialty building-block catalog provides compatible protected fragments and unusual scaffolds.

Research Use Only.