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DOTA-GA(tBu)4 is a protected bifunctional DOTA derivative that combines the 1,4,7,10-tetraazacyclododecane chelator framework with a glutaric-acid-derived conjugation handle. Four carboxyl functions are protected as tert-butyl esters, while one carboxyl group remains available for derivatization.
This reagent is most useful before metal loading. It provides a route for attaching a DOTA-type chelator to an amine-containing molecule and then removing the tert-butyl groups to expose the carboxylate-rich coordination environment. For a complete peptide project, Alan Scientific can evaluate the chelator together with the intended sequence through our chelating-group and modified peptide synthesis service.
Product Information
| Product Name | DOTA-GA-tetra(tBu-ester) |
| Normalized Chemical Name | DOTA-GA(tBu)4 |
| Catalog No. | AS2120 |
| CAS No. | 306776-79-4 |
| Molecular Formula | C35H64N4O10 |
| Molecular Weight | 700.91 g/mol |
| Chemical Identity | DOTA-GA(tBu)4; protected glutaric-acid-functionalized DOTA chelator precursor |
| Building Block Type | Protected bifunctional macrocyclic chelator |
| Primary Applications | Chelator conjugation, radiometal-labeling precursor chemistry and modified peptide synthesis |
GA Side Arm and Conjugation Role
The glutaric-acid-derived side arm provides a dedicated conjugation handle in addition to the macrocyclic chelator. Attachment geometry, linker length and conjugation site can affect accessibility of the final metal complex and should be defined during probe design.
Protected Chelator First, Metal Complex Later
The tert-butyl esters reduce premature carboxylate reactivity during synthetic assembly. After conjugation, acid-mediated deprotection can expose the DOTA carboxylates required for strong metal coordination. The protected starting material is therefore a chelator precursor rather than a ready-to-use radiometal complex. Metal loading, radiochemical purity and biological performance belong to the downstream conjugate, not to this reagent alone.
DOTA-GA(tBu)4 vs DOTA-tris(tBu ester)
The related DOTA-tris(tBu ester) precursor has three tert-butyl-protected acetate arms and one free acetic-acid arm. DOTA-GA(tBu)4 uses a different bifunctional architecture with a GA-derived handle and four tert-butyl esters. Matching the correct scaffold to a published route matters more than selecting solely by the word “DOTA.”
Procurement and QC Considerations
Confirm CAS 306776-79-4, formula C35H64N4O10 and molecular weight 700.91 g/mol on the lot-specific COA. For conjugation work, check the drawn structure and number of protected esters together with HPLC/MS identity. Handle the material under conditions appropriate to the intended workflow.
Product Documents
A Safety Data Sheet (SDS / MSDS) is available for this product to support laboratory handling, storage and safety assessment.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What is DOTA-GA(tBu)4 used for?
It is used as a protected bifunctional DOTA chelator precursor for conjugation to peptides and other amine-containing research molecules.
Can this protected reagent chelate a metal directly?
The tert-butyl-protected form is primarily a synthetic precursor. The protecting groups are normally removed before the final DOTA coordination environment is used for metal complexation.
Is DOTA-GA(tBu)4 the same as DOTA-tris(tBu ester)?
No. Their protecting-group counts and bifunctional side-arm architectures differ, so they should be selected according to the intended conjugation route.
Related Technical Resources
Compare the alternative DOTA-tris(tBu ester) scaffold.
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