[D-Arg1,D-Trp5,7,9,Leu11]-Substance P is a synthetic analog of Substance P incorporating D-arginine at position 1 and D-tryptophan at positions 5, 7, and 9, with leucine substituted at position 11. These modifications enhance its stability, resistance to enzymatic degradation, and binding affinity for neurokinin-1 (NK-1) receptors. This analog retains bioactivity in modulating pain signaling, inflammatory responses, and immune functions. Utilized in pharmacological research, it serves as a tool to investigate structure-activity relationships, receptor specificity, and explore therapeutic potential for analgesic and anti-inflammatory applications.

Chemical Formula: C81H110N20O12

Molecular Weight: 1555.91

Sequence: D-Arg-Pro-Lys-Pro-D-Trp-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH2

Purity: From crude to 98%

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Research Use Only