$285.71 - $857.14
Boc-N-Me-Ser-OH (CAS 101772-29-6) belongs to the n-methylated protected amino-acid building block class. It is used in backbone N-methylated peptide and peptidomimetic synthesis, particularly where backbone N-methylation, conformational tuning and proteolytic-stability/SAR studies is required.
N-methylation increases steric demand during coupling; reagent choice and coupling time may need adjustment relative to the unmethylated residue. Procurement should match the exact CAS, protection state and lot-specific analytical specification to the intended route.
Product Information
| Product Name | Boc-N-Me-Ser-OH |
| Catalog No. | AS4201 |
| CAS No. | 101772-29-6 |
| Molecular Formula | C9H17NO5 |
| Molecular Weight | 219.24 g/mol |
| Compound Type | N-methylated protected amino-acid building block |
| Primary Research Use | Backbone N-methylated peptide and peptidomimetic synthesis |
Backbone N-Methylation
Boc-N-Me-Ser-OH introduces an N-methylated amino-acid unit into peptide or peptidomimetic synthesis. Backbone N-methylation removes an amide hydrogen after incorporation and can alter local conformation, hydrogen bonding and proteolytic susceptibility.
Coupling Considerations
N-methylated residues are more sterically demanding than their unmethylated analogs. Difficult couplings may require stronger activation, longer reaction time or sequence-specific optimization rather than simple reagent excess.
Selection in SAR Programs
Use the exact residue and stereochemistry required by the design. N-methylation and side-chain changes should be treated as separate variables when interpreting conformational or activity effects.
Compare neighboring reagents in our noncanonical amino acids. Full-sequence work is covered under protected peptide building blocks.
Product Documents
MSDS - Boc-N-Me-Ser-OH (AS4201)
The Safety Data Sheet provides product identification, hazard information, handling and storage guidance, exposure controls, transport information, and regulatory information for laboratory use.
Certificates of Analysis (COAs) are batch-specific. Please contact us to request the COA for your product, and we will provide it by email.
Frequently Asked Questions
What does N-methylation change in Boc-N-Me-Ser-OH?
It removes a backbone amide hydrogen after incorporation and can alter local hydrogen bonding, conformation and proteolytic susceptibility.
Can Boc-N-Me-Ser-OH be more difficult to couple?
Yes. Its N-methylated backbone nitrogen is more sterically demanding than the corresponding unmethylated residue, so activation and reaction time may need sequence-specific adjustment.
Can the opposite stereoisomer replace Boc-N-Me-Ser-OH?
No. Stereochemistry and N-methylation are independent structural variables and can produce different peptide conformations.