[Asp5,6,Me-Phe8] Substance P is a modified analog of Substance P with substitutions at positions 5, 6, and 8: aspartic acid (Asp) residues replace native amino acids at positions 5 and 6, while a methylated phenylalanine (Me-Phe) is introduced at position 8. These modifications enhance its stability, receptor-binding affinity for neurokinin-1 (NK-1) receptors, and selectivity in modulating pain signaling, inflammation, and immune responses. Utilized in pharmacological research, this analog serves as a tool to investigate structure-activity relationships and explore therapeutic potential in analgesic and anti-inflammatory drug development.

Chemical Formula: C40H56N8O11S

Molecular Weight: 857.00

Sequence: Asp-Asp-Phe-Me-Phe-Gly-Leu-Met-NH2

Purity: From crude to 98%

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Research Use Only